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Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP 1 safety profile)
Food Sci Biotechnol 22, 341346.CrossRefGoogle Scholar Klebsiella pneumoniae
Long-Term Considerations Weight Regain After Discontinuation Both medications are associated with weight regain after discontinuation: STEP 1 extension data showed that participants who stopped semaglutide regained approximately two-thirds of their lost weight over the following year (Wilding et al., Diabetes, Obesity and Metabolism , 2022) Long-term data for tesofensine is more limited, but weight regain is expected given that the appetite-suppressing mechanism ceases when the medication is stopped This underscores the importance of viewing these medications as long-term or indefinite treatments for chronic obesity management, rather than short-term interventions
GLP-1 Tips: 5 Tips to Prepare for Shot Day GLP-1 (glucagon-like peptide-1) medications, such as Wegovy and Ozempic, have become increasingly popular in the treatment of type 2 diabetes and obesity
These effects are typically dose-dependent and often diminish over time with continued use