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Unlike many compounds that work through blood flow, PT-141 acts on the brain , targeting pathways involved in desire and motivation

Nat Protoc 2007;2:32933

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Combined treatment with ovastatin and lovastatin (a cholesterol-lowering agent) inhibited epidermal growth factor-induced migration of anaplastic TC cells ( in vitro and in vivo mouse model of anaplastic TC showed that troglitazone + Lovastatin display anti-cancer effects such as reduction of cell proliferation and tumor regression (Zhong et al., 2018)