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Researchers studying NAD+ biology or methyl-donor pools should evaluate primary sources directly and note that NNMT inhibition has distinct mechanistic implications compared to direct NAD+ precursor supplementation with molecules like NMN or NAD+ itself

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doi: 10.1007/BF02327082

Additionally, the harsh acidic environment of the stomach and/or dysfunctions in R-proteins (haptocorrins) that protect B12 in the stomach, and potential degradation by gastric enzymes can compromise the stability and bioavailability of oral B12 supplements

It is injected directly into the body