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The KELCH domain of the Keap1 homodimer binds to the DLG and ETGE motifs (ETGE acts as a hinge, and DLG acts as a latch) of the Neh2 domain of Nrf2 in the cytosol

The SmPC notes that semaglutide delays gastric emptying, which could potentially influence the absorption of some oral medications

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Self-directed patients

A more nuanced takeaway is that biological ratios can matter as much as absolute numbers

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