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Interestingly, not only the silencing of LDHB but also the inhibition of GPX4 results in significant mitochondrial lipid peroxidation, which is in agreement with the known mitochondrial function of GPX4 19

More promising, perhaps, are multi-target approaches that simultaneously enhance EAAT2 function and reduce oxidative stress, potentially offering a more robust neuroprotective effect [403]

Deficiencies in other micronutrients, including vitamin B 6 , vitamin B 12 , and omega-3 fatty acids, have been linked to depression, and vitamin D deficiency has also been associated with negative effects on mood (51, 144)

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