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FOXO4-DRI (Proxofim) is a D-retro-inverso senolytic peptide that selectively clears senescent "zombie" cells by disrupting the FOXO4-p53 survival interaction

The investigators conducted a multicenter, double-blind, placebo-controlled, active-controlled phase 3a trial (ClinicalTrials.gov ID: NCT05567796) evaluating the efficacy and safety of the combination of semaglutide and cagrilintide in adults without diabetes with a body-mass index (BMI) of greater than or equal to 30 or greater than or equal to 27 with at least one obesity-related complication

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Addressing mitochondrial dysfunction, redox imbalance, and impaired energy metabolism could lead to more effective treatments

Out-of-Specification (OOS) investigations that lacked scientific justification

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