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If concomitant use of a CYP3A4 inhibitor is necessary or if a CYP3A4 inducer is discontinued, consider dosage reduction of acetaminophen and codeine phosphate tablets until stable drug effects are achieved

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Custom formulations or large MOQs may extend to 2130 days

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OA is a complex disease influenced by various factors including the natural aging process, gender, genetic predisposition, obesity, and physical factors (e.g., joint trauma and injury) 5