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It also appeared that BPC-157 may have regulated the phosphorylation level of extracellular signal-regulated kinases 1 and 2 (ERK1/2) and their downstream targets, including c-Fos, c-Jun, and Egr-1

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Modulators of the p53 pathway, such as FOXO4-DRI and MDM2 inhibitors, selectively eliminate senescent cells but face challenges in clinical translation

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