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The remodeled microbiome composition further optimizes the integrity and permeability of the intestinal barrier via Occludin, ZO-1, Claudin-2, and Mucin 2 (MUC2), at the same time suppressing the activity of M1-type macrophages, thereby improving the clinical indices of bone health, including BMD, BV/TV, and Tb

Findings: In animal studies, long-acting GLP-1 analogs improved glucose tolerance and enhanced insulin response, supporting their role in metabolic regulation

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610 Actovegin improved neuropathic symptoms, vibration perception threshold (VPT), sensory function, and quality of life in patients with DPN in a multicenter, randomized, double-blind trial

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