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Pre-existing health conditions: Individuals with certain health conditions, such as hypothyroidism, polycystic ovary syndrome (PCOS), or insulin resistance, may experience slower weight loss despite using Tirzepatide

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This is part of what reduces hunger, but it can also cause nausea, bloating, and discomfort if you eat the wrong foods or eat too much at once

Because of the 2026 rules below, the provider should document a real patient-specific reason

Inject ZEPBOUND under the skin (subcutaneously) of your stomach (abdomen), thigh, or another person should inject in the back of the upper arm

Animal studies found an increased risk for colorectal cancer, although that risk hasn't been shown in humans