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The 2016 meta-analysis (Pooyandjoo, PMID 27335245) pooled trials of varying length and found a mean 1.33 kg difference versus control, but its meta-regression reported that the weight advantage shrank as supplementation continued so the weight effect does not compound across this window the way recovery adaptations do

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[DOI] [PMC free article] [PubMed] [Google Scholar] 141.Blundell J., Finlayson G., Axelsen M., Flint A., Gibbons C., Kvist T., Hjerpsted J.B

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[3] What Happens When Gut NAD+ Is Depleted The same research team found that obese mice fed a high-fat diet showed the same pattern: compromised intestinal NAD+ biosynthesis, impaired GLP-1 production, and disrupted postprandial glucose metabolism