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Constipation may first appear during this phase

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Gomez N, Touihri K, Matheeussen V, Mendes Da Costa A, Mahmoudabady M, Mathieu M, Baerts L, Peace A, Lybaert P, Scharpe S, et al: Dipeptidyl peptidase IV inhibition improves cardiorenal function in overpacing-induced heart failure

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However, over the last several years, effective medical therapies for HFpEF have been established demonstrating significant improvements in patient-centered outcomes in those affected by HFpEF