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British Journal of Nutrition , 97(3), 447457

Laboratory investigations often examine lipotropic compounds in experimental models evaluating hepatic lipid metabolism, mitochondrial energy pathways, and cellular metabolic signaling

In wild-type mice, cagrilintide activates c-Fos-expressing neurons in the dorsal vagal complex (DVC), lateral parabrachial nucleus (LPBN), area postrema, and nucleus tractus solitarius brainstem regions critically involved in satiety signaling and suppression of food intake

These benefits, observed across a heterogenous population, suggest that retatrutide could do more than just reduce liver fat and could potentially deliver wider protection for cardiovascular and metabolic health