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Statistics and reproducibility Statistical analyses were conducted via the TriNetX platform, incorporating Java 11.0.16 (Apache Commons Math 3.6.1), R 4.0.2 (Hmisc1-1, Survival 3.2-3), and Python 3.7 (lifelines, matplotlib, numpy, pandas, scipy, statsmodels)

The cost premium is real but small

The rest of the list, including Ozempic, Mounjaro, and Trulicity, is approved for type 2 diabetes, though they affect weight through the same mechanism

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Most injection site reactions are mild and self-limiting, requiring only observation and basic symptomatic management

dose escalation protocols minimise these effects Injection site reactions : erythema, pruritus, or mild discomfort at subcutaneous injection sites Serious but less common risks include: Pancreatitis : patients should be counselled to seek immediate medical attention if experiencing severe, persistent abdominal pain radiating to the back