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In the ACHIEVE-1 trial for type 2 diabetes, patients on the highest dose of orforglipron (36 mg daily) achieved an average A1C reduction of approximately 1.6% and lost around 9.4% of their body weight over 40 weeks

Concerns of potential mental health conditions in people with obesity have accompanied the development of medications for chronic weight management, which

It's a cycle that feeds itself

Increased health and longevity could put more money in people's pockets through things like lower healthcare costs, insurance premiums, groceries, and fewer trips to restaurants, in addition to potentially earning more over their lifetimes by staying in the workforce longer

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By 18 months after discontinuation, most patients have returned to their baseline weight, erasing the majority of their progress