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doi: 10.1016/j.cmet.2020.03.004

Notably, their small size facilitates transport across the BBB via endocytosis, followed by biodegradation within the brain microenvironment, which results in the controlled release of the encapsulated drug [108]

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They were kept in plastic cages under the environmental conditions were kept at 23 C, 14-hr light and 10-hr dark cycles

A2A receptor activation upregulates vascular endothelial growth factor (VEGF), promotes angiogenesis in dermal microvasculature, stimulates fibroblast migration and proliferation, and suppresses inflammatory cytokine release