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This combination has become increasingly popular among researchers due to its ability to target multiple components of the growth hormone axis while maintaining a distinct mechanism of action for each peptide

doi: 10.1369/0022155417751880 134 KarkhaneiB.Talebi GhaneE.MehriF

Current ongoing trials are now investigating triple agonism with examples including retatrutide, targeting GLP-1, GIP, and glucagon receptors [4]

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For affinity fusion proteins, the appended protein will bind to a third, typically small, molecule that is immobilized on the surface of a polymer resin