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Structural analyses indicate that -amylase activity requires calcium ions to maintain structural integrity and is activated by chloride ions, and similarly, -glucosidase operates via a Koshland double displacement reaction mechanism (64)

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This leads to enhanced vasodilation, increased permeability, and mucosal congestion and edema, resulting in abdominal pain and diarrhea [115] (Fig

Viewed together, these findings suggest that MOR may be expressed in the DMV and may contribute to morphine-induced DMV Ach neuronal hypoactivity

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