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Research shows that IGF-1 levels are already elevated in major depressive disorder (MDD) and bipolar disorder , and adding more could worsen underlying dysregulation

This was evident by the inhibition of JNK, ERK and p38 phosphorylation and downregulation of cyt- C, Bax, cleaved CASP-3 and upregulation of BCL2 [139]

NAC alleviates xCT system dysfunction caused by RGS4 deficiency by preserving cysteine and glutamate exchange, offering a targeted method to restore glutamatergic signaling in the prefrontal cortex for this schizophrenia subtype