It might be the dose, the titration speed, a concurrent medication, an underlying condition, or a shift to a different GLP-1 medication entirely (tirzepatide, for instance, shows stronger average weight loss in head-to-head comparisons)
While it was originally designed for type 2 diabetes, its ability to reduce hunger has made it a core component of modern weight management
Mechanism: Slowed gastric emptying and activation of GLP-1 receptors contribute to nausea
This connection is seen in both diabetic and non-diabetic individuals using the drug for weight management
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The response was dose-dependent, with higher doses producing slightly more fat loss, though the dose-response curve flattened at higher levels (Thompson et al., 2004)