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10.1038/nature05859 170 YangJ.WangC.ChengS.ZhangY.JinY.ZhangN.et al (2023)

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Another 24 per cent to 30 per cent of participants also had constipation and vomiting, although these were mild to moderate, with the symptoms diminishing with continued use. Dr Wong also noted anecdotal reports of psychological effects such as mood changes, anxiety and stress