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Bull World Health Organ 86:480487 Taher AT, Cappellini MD (2018) How I manage medical complications of beta-thalassemia in adults

While short-term fasting decreases serum IGF-I but does not affect GHBP (69), the triad of IGF-I deficiency, poor growth and pubertal delay/arrest in long term nutritional deficiency such as in anorexia nervosa is associated with low GHBP that is partly restored with weight gain (63)

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Evidence & regulatory status Evidence: weak and contested the foundational sleep-inducing effect described in 1970s animal studies has not been reliably replicated in controlled human research