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J.DedeogluA.MuellerG.LancelotE.BogdanovM.AndersenJ
Gastrointestinal Side Effects The most common adverse events were gastrointestinal in nature, as expected for this drug class: Nausea the most frequently reported GI side effect, typically most pronounced during dose escalation and diminishing over time Diarrhea reported at moderate frequency Constipation less common than nausea but clinically relevant for some participants Vomiting generally mild and often transient These GI effects are mechanistically linked to GLP-1 receptor activation (slowed gastric emptying, central appetite suppression) and are a recognized feature of all GLP-1-based therapies
PS, phosphatidyl serine
The takeaway: Research shows that long-term usage of GLP-1 drugs, like Ozempic, can increase patients odds of developing age-related macular degeneration, which, in many cases, can result in total blindness
Tirzepatide: A novel glucose-dependent insulinotropic polypeptide/glucagon-like peptide 1 receptor agonist for the treatment of type 2 diabetes: The first twincretin
5 a,b,c, reveal a pronounced concentration-dependent and time-dependent antifungal effect
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