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Ecotoxicol Environ Saf 78:195205 Wu JP, Ma BY, Ren HW, Zhang LP, Xiang Y, Brown MA (2007) Characterization of metallothioneins (MT-I and MT-II) in the yak

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In the case of aging, it is known that over time, mitochondrial dysfunction occurs in parallel with NAD + depletion in muscle tissues, and often this depletion has been linked to muscle wasting or loss of muscle function 240,241

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Microscopically, the principal correlate is a so-called shoulder area of lentiginous junctional melanocytic proliferation beyond the lateral border of the underlying dermal component