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Similar content being viewed by others Introduction Gastric cancer (GC) ranks as the fifth most frequently diagnosed cancer and the fourth most common cause of cancer death globally 1

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9 Proof-of-concept treatments were tested on patient fibroblasts and Pfa1 cells, which were knocked out of endogenous GPX4 and transfected to overexpress human mScarlet-tagged GPX4 WT (red) or GPX4 R152H (blue)

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One of the most prominent features of hypoxia-induced metabolic reprogramming is the excessive production of lactate, resulting from enhanced glycolysis in both cancer cells and stromal components like cancer-associated fibroblasts (131)

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