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Research published through 2025 and 2026 has established that 25% to 40% of total weight lost on high-efficacy GLP-1 medications comes from lean mass rather than fat, according to multiple DXA-based body composition studies

Some weight regain is common after stopping any weight-loss intervention diet, exercise, surgery, or medication

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For evidence-based nutritional support while on prescription GLP-1, see best GLP-1 supplements

Cyanocobalamin (B12) plays a critical role in energy metabolism by aiding in the formation of red blood cells, supporting nerve health, and facilitating DNA synthesis