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CSE-induced lipid peroxidation and iron redistribution in HCE-T cells CSE contains numerous chemicals that induce the production of reactive oxygen species (ROS), which evoke lipid oxidation and activate cell death signaling pathways 6

(4) Competitive nicotine blockade: By occupying 42 receptor binding sites, varenicline prevents nicotine from fully activating these receptors, thereby diminishing the rewarding effects of tobacco use

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