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In over-accumulated WAT, fatty acid by-products, mainly diacylglycerol (DAG), are metabolized through -oxidation in the tricarboxylic acid (TCA) cycle, and under the DAG stimulation of PKC, the NADPH oxidase is directly activated to generate excess ROS [145]

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Beyond that, one sample showed traces of endotoxins (a potential signal for bacteria), although no specific pathogen was detected