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On the same day of infection, PBMCs were either sham treated (untreated) or treated with 1/10 the minimum inhibitory concentration 1/10 MIC of PZA (5 micrograms/ml), and (MIC) of INH (0.125 micrograms/ml)

20,21 Based on studies of genetically modified mice, considerable progress has been made in illustrating the functions of genes such as Mecp2 (Rett syndrome), Tsc1/2 (tuberous sclerosis), Fmrp (fragile X syndrome), Pten and Shank3 (PhelanMcDermid syndrome) in several monogenetic diseases

In the first case, GSH synthesis is blocked, so the rapid export of GSH makes the GSH concentration decline rapidly

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doi: 10.1016/j.cell.2022.06.003 23 StockwellBRJiangXGuW

doi: 10.1016/s0006-2952(97)00480-2