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Down-regulation of CFL1 or decreased CFL1 phosphorylation can alleviate erastin-induced HT22 cell death and reduce the glutamate-induced excitotoxicity of primary cortical neurons [135]

In terms of molecular type/formulation, small molecules account for 67% (31/46, including one peptide with a molecular weight of 749.2), antibody and related formulations represent 20% (9/46), and the remainder (ADC, fusion proteins, siRNA/ASO, etc.) make up 13% (6/46) (see Figure 1)

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they have biological roots

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