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* Author Details: Hoek is a Professor of Public Health (and was formerly a Professor of Marketing)

But the last thing they might expect is that the device may explode right in their hands, causing serious injury and even death

Studies have reported acute changes in airway epithelial permeability due to oxidative stress and inflammation, and junction proteins gradually decomposed after long-term CS exposure, leading to the structural destruction of airway epithelial barrier [10,11,12]

Changes in the gut microbiome during HS can also lead to reduced production of anti-inflammatory SCFAs, which in turn inhibit pattern recognition receptors (PRRs) involved in pathogen recognition and reduce the production of IL-10 and TGF- (218)