tirzepatide and retatrutide together vs. Tirzepatide: The Next-Gen GLP-1 Showdown Will Retatrutide Replace Tirzepatide

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ADR: Major- GI No hepatic or renal adjustment Has not been studied in patients with history of pancreatitis Boxed Warning: Risk of thyroid C-cell tumors Note: The combined use of GLP-1 RAs, Tirzepatide, and/or DPP-4 Inhibitors (eg, Sitagliptan) NOT recommended due to their similar MOA

These may include mild headache, dizziness, fatigue, or slight nasal irritation

Tirzepatide may decrease the exposure to oral contraceptives

When counseling patients concerned about access or cost following Medicare coverage changes, clinicians can use real-world data like this to reinforce that the therapeutic value of GLP-1s is well-documented, and that exploring alternative coverage pathways or manufacturer assistance programs is worth pursuing before discontinuing therapy

Do I have a plan if weight starts creeping back