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[11] Many people with schizophrenia have smoked tobacco products long before they are diagnosed with the illness, and a cohort study of Israeli conscripts found that healthy adolescent smokers were more likely to develop schizophrenia in the future than their nonsmoking peers

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Individuals with reduced renal function require dose adjustments to prevent drug accumulation

Both substances affect your central nervous system , and their combined depressant effects intensify each other