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J Neurosci 31(17):65876594 Hansen HH, Barkholt P, Fabricius K, Jelsing J, Terwel D, Pyke C, Knudsen LB, Vrang N (2016) The GLP-1 receptor agonist liraglutide reduces pathology-specific tau phosphorylation and improves motor function in a transgenic hTauP301L mouse model of tauopathy

Additionally, N-acetylcysteine increases the expression of Bcl-2 to inhibit apoptosis in KTEC cells by upregulating SIRT3 expression to exert protective effect against SAKI (Fan et al., 2024)

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However, no single mouse model accurately recapitulates the integrated metabolic, histological, and molecular complexity of human disease