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A high-fat diet is associated with endotoxemia that originates from the gut

No known pharmacokinetic conflict

It also increases strength and single-repetition exercise volume, reduces fatigue, and improves endurance for high-intensity exercise FASTER RECOVERY & OPTIMIZED WORKOUT PERFORMANCE - Creatine may help increase energy during exercise, naturally building endurance and strength to make daily activities and workouts more productive and enjoyable

Bibcode:2004NYASA1033