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A Phase 2b clinical trial (Heffernan 2007, 300 obese patients) tested 1 mg/day subcutaneously over 12 weeks with a weight loss result of ~2.8 kg vs placebo

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India Patent expires: March 2026 Adult population: 947 million Proportion of adults living with obesity a : 8% Proportion of adults living with diabetes b : 11% China Patent expires: March 2026 Adult population: 1.07 billion Proportion of adults living with obesity a : 9% Proportion of adults living with diabetes b : 12% Brazil Patent expires: March 2026 Adult population: 155 million Proportion of adults living with obesity a : 31% Proportion of adults living with diabetes b : 11% Trkiye Patent expires: 2026 Adult population: 59.0 million Proportion of adults living with obesity a : 36% Proportion of adults living with diabetes b : 16% Canada Patent expires: 2026 Adult population: 29.1 million Proportion of adults living with obesity a : 27% Proportion of adults living with diabetes b : 10% World Population: 8.23 billion More than 1 billion people in the world have a body mass index (BMI) 30 kg/m 2

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