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The liver then oxidizes TMA into trimethylamine N-oxide (TMAO)

Genetic evidence, knockout models, and selective agonist trials all confirm that MC4R signaling regulates appetite in humans

Subjects who supplemented with carnitine were able to increase their energy output by 11%

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These results, presented today at the 2026 Scientific Sessions of the American Diabetes Association (ADA) and simultaneously published in The Lancet , mark an important step in building AstraZenecas differentiated weight management portfolio of monotherapies and combinations, supported by the Company's broad CVRM pipeline and global commercial expertise