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Common reasons include indigestion, acid reflux, gas buildup, constipation, food intolerances, infections such as gastroenteritis, and sometimes more serious conditions like ulcers or appendicitis

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1), while the sugar moiety, through its hydroxyl groups, is close to the main chain carbonyls of G323 and R322 in one conformation and with the analogous groups of G437 and Q440 occupying the hydrophilic portion of subpocket A in the other conformation