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One potential indirect mechanism involves severe gastrointestinal adverse effects

The HRH2 gene is also expressed in additional cells of the gastrointestinal tract, cells of the central nervous system, smooth muscle cells, endothelial cells, and cardiomyocytes

Localization of glutaredoxin (thioltransferase) in the rat brain and possible functional implications during focal ischemia

In various interviews and updates, she makes it clear that her transformation has come through traditional means rather than medication

10.1002/iub.1616 11 GioulekaS.TsakiridisI.ArsenakiE.KalogiannidisI.MamopoulosA.PapanikolaouE.et al (2023)