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Studies utilizing 'mini-brains' or organoids derived from patient stems cells, particularly those with MEF2C haploinsufficiency syndrome, have demonstrated excessive electrical activity and an imbalance between excitatory and inhibitory signaling

Zheng YB, Huang YT, Gong YM, et al

J Fungi (basel) 7:531

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4.3.2 Methodological limitations and clinical strategies Existing studies generally treat pregnancy-related outcomes as secondary or exploratory endpoints and seldom report analyses stratified by weight-loss achievement, insulin-resistance improvement, or washout structure (111, 112, 124)