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Cocaine Only limited clinical evidence is available for GLP-1RAs in cocaine misuse: a small ( N = 13) proof-of-concept trial across 2 days showed that exenatide compared with placebo did not reduce the number of self-administered cocaine infusions 115 , while a case series of 3 individuals with cocaine-use disorder highlighted the feasibility and safety of using the same drug over 6 weeks, although no efficacy measures were reported 116

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Manufactured by Novo Nordisk, Rybelsus is the first and only oral GLP-1 receptor agonist for managing type 2 diabetes

A cold pack applied for 15 to 20 minutes can help

It is structurally similar to the naturally occurring human GLP1 hormone , with specific modifications that improve its stability and extend its duration of activity in research settings

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