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And while some companies, such as Lilly, are testing their analogs as stand-alone therapies, others, including Novo Nordisk, are combining them with GLP-1s

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[31] provide an overview of pathways involving hypothalamic satiety signaling, ghrelin suppression, and improved insulin and lipid metabolism

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While they can deliver powerful benefits glucose control, heart and kidney protection, and even weight loss - drug makers have either stopped or refrained from starting additional clinical trials, leaving regulators without the data needed to approve use in type 1