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GLP-1 activation is also associated with delayed gastric emptying, another contributing factor to appetite suppression and thus reduced food intake

In addition to the well-known effects of GLP-1 and GLP-1 RA in improving insulin sensitivity and reducing body weight, at central levels, GLP-1 and GLP-1 RA might exert regulating effects on GhRH release, and on concomitant gonadotropin secretion, likely by activating the kisspeptin hypothalamic system, a key regulator of the pulsatile release of GnRH from GnRH neurons

Worth Publishers, pp

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Although the initial damage to the brain seemed to be similar between treatment and control groups, the researchers noticed differences in how the brain degenerated over time

Gradual, Steady Progress Weight loss with GLP-1 medications tends to be gradual and sustained when combined with healthy lifestyle habits