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Further, many chemotherapy agents undergo drug metabolism by reductase enzymes that are fuelled by an NADPH cofactor, with NADP + and NADPH levels dependent on the availability of NAD + as a substrate for NAD + kinase

H&E staining results further confirmed that the aortic wall thickness of mice treated with FOXO4-DRI was significantly thinner, and ultrasound examination results showed that the PWV of the aorta was slowed down after FOXO4-DRI treatment, indicating better vascular elasticity and significantly improved vascular function compared to the control group (Figures 2D,E)

Due to this evidence, some researchers believe that herpesviruses as one of the causes of ME/CFS is a fading hypothesis (150)