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Am J Respir Crit Care Med 171 : 431439 Fitzpatrick AM, Brown LA, Holguin F, Teague WG, National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program 2009 Levels of nitric oxide oxidation products are increased in the epithelial lining fluid of children with persistent asthma

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We remark that one would not expect the contributions of the two metabolites to GSH synthesis to be strictly proportional to their inputs since they are used in other reactions and the system is highly non-linear

However, when combined with other skin-lightening ingredients like vitamin C, they can help improve skin tone and reduce dark spots over time