weight regain after stopping semaglutide trial cessation of medication for weight management: systematic review and meta-analysis November Blog - What happens

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STEP 3 Trial : Participants who combined semaglutide with intensive behavioral therapy and a low-calorie diet experienced even greater weight loss, averaging around 16% of their body weight

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Cognitive improvement cannot be fully attributed to metabolic recovery, as body weight dissociation tends to suggest direct central effects