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In this scheme, both executive and threat/arousal circuits are functioning normally at the biological level, but their feedback interactions produce a vicious cycle of anxiety and distorted cognitions

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J Alzheimer's Dis 40:519529 Gu M, Owen AD, Toffa SE, Cooper JM, Dexter DT, Jenner P, Marsden CD, Schapira AH (1998) Mitochondrial function, GSH and iron in neurodegeneration and Lewy body diseases

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Peak plasma concentration occurs 2448 hours post-injection, but therapeutic receptor occupancy persists throughout the seven-day interval