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Heres the data and why it varies

The time-series models in essence examine difference scores for the variables that are weighted by the size of the estimated serial correlation coefficient

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Illumina 450K Methylation BeadChip ( Illumina GoldenGate Assay for Methylation (McRonald et al., 2009): This platform utilizes pre-selected CpG sites within genes relevant for specific diseases or pathways, such as the GoldenGate Methylation Cancer Panel I, which spans 1,505 CpG loci from 807 cancer-related genes