For example, in the case of Enterococcus amplification culture, if the inoculation density is too low, the production strain may undergo genetic mutations and completely lose the ability to produce the target product [217]
The theoretical mechanism for concern exists
In some studies, telomere length rose by an average of 33.3%, though results varied between individuals, likely due to differences in baseline telomerase activity, cellular age, and other metabolic factors [4, 14]
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