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IGF-1 levels increase significantly but remain within safety thresholds, and no glycemic worsening occurs in type 2 diabetes patients at therapeutic doses

Thal et al

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But its too soon to say how effective it might be, and any new uses would require separate FDA approval once the studies are complete

Information about ongoing UK trials can be found via the NIHR Be Part of Research website (bepartofresearch.nihr.ac.uk) or the ClinicalTrials.gov database

While the liver was previously thought to be the main target of metformins glucose-lowering effects, recent evidence suggests that other parts of the body, such as the gastrointestinal tract, also play a role in its overall clinical advantages